I replied to another post with a list of mods, so take a look at the other comments in the post for some out of box mods.
As a 350 owner, be aware of two things.
First, big bed = big chamber = heat soak takes a while and you have a lot more surface area to lose heat from. If you want to print big ABS/ASA parts you’re going to want ACM panels, a better sealed/insulated front door, and potentially a radiant layer inside the printer.
Second, the big printer limits your rate of acceleration some compared to a smaller CoreXY. IMO if you have a big printer to print big things you’re probably not going to have small/finely detailed parts that often. Those are the kinds of parts that will go a touch slower. But honestly 5k acceleration is orders of magnitude faster than most bed slingers can achieve and 10-15k is only a 2-3x increase so you’re not giving up that much.
Other than than, no regrets about the 350.
Print duration is dependent on two components:
My print speed is often limited by volumetric flow - not the actual speed of my print head, so I haven’t bothered chasing higher ceilings. Granted, tend to print I print large/chunky/functional things so my goal is to lay down as much material as possible. If you’re chasing lots of fine detail, a smaller Voron can go faster than what I have but isn’t going to be that much faster than where you are now.
Thanks to a combination of CoreXY (rigidity) and Klipper (pressure advance, input shaping), I have basically zero ringing/ghosting show up in prints. It is worth talking about quality expectations though. Harsh lighting can reveal that layer lines are not perfectly aligned layer to layer. Not sure if this is a Voron thing or is it’s just more obvious now that my layers are a lot more noise free.
Automated gantry leveling (Klipper will get the bed and gantry to be ‘perfectly’ in plane thanks to 2.4s being able to mechanically move the four corners of the gantry independently - trident does similar, but moves the bed instead), a klicky probe and a Z calibration macro, and bed mesh make my first layers extremely consistent print to print.
One caveat: because the printer is enclosed and big (if you go for a 350), if you print sequential objects without letting the printer fully heat soak, the first layer will progressively get a touch higher and higher between prints as the printer expands in the z-axis.