I think you already gave yourself the answer in your own case:
Because I give zero crap about what other people think of me.
This applies to people that aren’t in your inner circle. You want HER to be in that circle and suddenly it actually does matter what SHE thinks of you. You have little to lose with people you don’t really care about, but everything to lose with people you do care about. It’s an evil social twist that makes everything so complicated. High self-esteem is just the ability to quickly pull yourself up when you fall and the knowledge that you actually CAN do so. It mitigates the risks of “putting yourself out there”.
I had no cancer, but know people that did and one thing that came up often is that people tend to distance themselves from them. Not in a mean way, but dealing with special needs is tedious and that is often just a cause to not do certain things. Spending time together (no matter what you end up doing) gives a sense of normalcy and can really push someone to keep fighting. Cancer is a marathon with additional sprints (chemo) on top. Not being alone through all of this is a huge help