I run arch exclusively and find gaming to be pretty seamless and enjoyable, but it does require some config. This is mostly because arch makes no assumptions so dependencies installed by default on other systems are likely not present unless you installed them.
I suggest running Lutris since it handles wine prefixes. Wine prefixes essentially do the work of keeping your individual game installs compartmentalized so each game has all the required dependencies to run properly.
Regardless of whether you use Lutris, the maintainers of that software have good documentation on installing wine and its dependencies here. The guide has a section for Arch and is particularly helpful for ensuring you have all appropriate vulkan or nvidia drivers and driver dependencies installed.
Best of luck if you decide to go down the arch path!
Are you running these in docker? If so read on otherwise this probably won’t help you.
I encountered a similar problem with my Sonarr/Radarr setup and Prolwarr indexer. I would have no results in sonarr/radarr but would have results when searching directly in prowlarr. Ultimately I discovered it was a dns issue.
I had a custom domain setup to access my sonarr/radarr services (eg., sonarr[.]mydomain[.]com). When I’d search through either sonarr or radarr the program would ping Prowlarr, but prowlarr would send the results back to the internal docker ip and not through to my custom domain. So I was seeing no results. My solution was to just access sonarr/radarr with their designated ips and ports rather than my custom domain.
Hope you are able to figure it out.