Dude is also situationally gender neutral. Saying “Hey dude” to a trans woman is misgendering her but exclaiming “Yo dude check this out!” or “Duuuude no way” is perfectly acceptable.
Neverwinter Nights 2 and BG2 had 9th level spells in a real time with pause game and it worked fine. So it is totally doable, especially since BG3 is turn based.
Dude is also situationally gender neutral. Saying “Hey dude” to a trans woman is misgendering her but exclaiming “Yo dude check this out!” or “Duuuude no way” is perfectly acceptable.