Mine live outside in the garage , I built a Corsi-Rosenthal box (box fan with a bunch of filters on it) that stays on out there, and both of mine are in fairly decently sealed enclosures with HEPA+Carbon recirc filters.
Don’t go in there when printing unless absolutely necessary, and even then, minimise exposure.
First computer I built had a BFG 7600gt with the first upgrade I ever did was a BFG 8800gt
Miss BFG and EVGA for nvidia cards.